ESM1

Across TCGA cell cohorts, ESM1 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ESM1-associated genes across cancer lineages are GUCA2A, IQCF5, and KRTAP7-1. Each is linked with ESM1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ESM1-to-partner and partner-to-ESM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GUCA2A grouped by ESM1-low versus ESM1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ESM1→partner) and Y-score (partner→ESM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GUCA2A →	+0.052	+5.969	<.001	.001	3	1
BLOOD_Leukemia	IQCF5 →	+0.124	+5.201	<.001	.006	3	1
BLOOD_Leukemia	KRTAP7-1 →	+0.095	+5.539	<.001	.003	3	1
LARGE_INTESTINE	CLDN17 →	+0.042	+3.345	.005	.007	3	1
LARGE_INTESTINE	COX6A2 →	+0.068	+4.022	<.001	.006	3	1
LARGE_INTESTINE	RBMXL2 →	+0.111	+3.554	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

GUCA2A by ESM1 expression — BLOOD_Leukemia

Explore this box plot interactively →