ESD

Across TCGA pan-cancer cohorts, ESD mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated ESD data layer compared with 23 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher ESD mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated ESD expression acts as an unfavorable survival marker, although some lineages such as PDAC and LUAD show a favorable association.

UCEC, PDAC, and LUAD are the cancer types where ESD mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	II,III,IV	0.567	1.000	.004	40	view →
PDAC	OS	Median	All	0.889	0.809	.017	16	view →
LUAD	DFS	Quartile	All	0.788	0.438	.002	13	view →
LSCC	DFS	Tertile	II,III,IV	0.865	1.000	.025	7	view →
CCRCC	DFS	Median	III,IV	0.818	0.244	.031	3	view →
GBM	OS	Quartile	All	0.545	0.892	.010	3	view →
HNSC	DFS	Tertile	III,IV	0.909	0.722	.046	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

ESD–UCEC (OS)

Open the UCEC breakdown →