ESCO2

Across TCGA cell cohorts, ESCO2 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ESCO2-associated genes across cancer lineages are MS4A4A, OR10W1, and TAFA1. Each is linked with ESCO2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ESCO2-to-partner and partner-to-ESCO2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MS4A4A grouped by ESCO2-low versus ESCO2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ESCO2→partner) and Y-score (partner→ESCO2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MS4A4A →	+0.182	+3.000	<.001	.006	3	1
LARGE_INTESTINE	OR10W1 →	+0.014	+3.562	<.001	.002	3	1
LARGE_INTESTINE	TAFA1 →	+0.234	+3.103	.002	.004	3	1
LARGE_INTESTINE	C14orf180 →	+0.155	+3.477	<.001	.001	3	1
LARGE_INTESTINE	LCN8 →	+0.137	+3.125	<.001	.008	3	1
LARGE_INTESTINE	NAT8B →	+0.896	+3.667	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

MS4A4A by ESCO2 expression — LARGE_INTESTINE

Explore this box plot interactively →