ESCO1

Across TCGA patient cohorts, ESCO1 mutation is significantly associated with the RNA expression of many other genes, with 3,725 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ESCO1-associated genes across cancer lineages are RNA5SP48, RN7SL22P, and CYCSP49. Each is linked with ESCO1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ESCO1-to-partner and partner-to-ESCO1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP48 grouped by ESCO1-low versus ESCO1-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ESCO1→partner) and Y-score (partner→ESCO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RNA5SP48 →	+0.488	+4.684	<.001	.001	3	2
LUAD	RN7SL22P →	+0.375	+4.037	<.001	.004	3	2
BLCA	CYCSP49 →	+0.909	+3.527	<.001	.007	3	2
COAD	UBE2V1P3 →	+0.087	+4.136	<.001	.008	3	2
UCEC	NDUFAF5 →	+0.367	+2.029	<.001	<.001	3	2
UCEC	PFN1 →	+0.264	+2.177	.007	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,725 associations by consensus.

RNA5SP48 by ESCO1 expression — LUAD

Explore this box plot interactively →