ERVMER61-1

Across TCGA patient cohorts, ERVMER61-1 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ERVMER61-1-associated genes across cancer lineages are C-Raf, p27, and PDK1_pS241. Each is linked with ERVMER61-1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ERVMER61-1-to-partner and partner-to-ERVMER61-1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C-Raf grouped by ERVMER61-1-low versus ERVMER61-1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ERVMER61-1→partner) and Y-score (partner→ERVMER61-1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C-Raf →	+0.157	+3.169	.046	.020	3	1
UCEC	p27 →	-0.276	-3.169	.021	.020	2	1
UCEC	PDK1_pS241 →	+0.214	+3.183	.022	.010	1	1
UCEC	ASNS →	+0.459	+3.169	.020	.020	1	1
UCEC	Bcl-2 →	-0.402	-3.143	.034	.020	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

C-Raf by ERVMER61-1 expression — UCEC

Explore this box plot interactively →