ERVMER61-1

Across TCGA pan-cancer cohorts, ERVMER61-1 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated ERVMER61-1 data layer compared with 2 for mutation status.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher ERVMER61-1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ERVMER61-1 expression acts as an unfavorable survival marker, although some lineages such as UVM and TGCT show a favorable association.

KIRP, BRCA, and CESC are the cancer types where ERVMER61-1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Tertile	All	0.801	0.938	<.001	132	view →
BRCA	OS	Tertile	II,III,IV	0.815	0.922	<.001	120	view →
CESC	OS	Tertile	III,IV	0.106	0.767	<.001	72	view →
LIHC	OS	Tertile	All	0.358	0.574	<.001	68	view →
UVM	OS	Tertile	All	0.893	0.456	.002	56	view →
KICH	OS	Tertile	III,IV	0.178	0.847	<.001	45	view →
SKCM	DFS	Quartile	III,IV	0.508	0.727	.002	42	view →
STAD	DFS	Tertile	IV	0.239	0.776	.012	40	view →
BLCA	DFS	Tertile	All	0.320	0.532	.008	35	view →
LGG	DFS	Tertile	All	0.643	0.840	.001	33	view →
LUAD	DFS	Tertile	IV	0.671	0.893	.019	30	view →
UCEC	DFS	Tertile	All	0.534	0.670	.012	30	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

ERVMER61-1–KIRP (DFS)

Open the KIRP breakdown →