ERVK9-11

Across TCGA pan-cancer cohorts, ERVK9-11 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of ERVK9-11’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where ERVK9-11 RNA is repressed in tumor relative to normal tissue. In most cancer types ERVK9-11 is over-expressed in tumor, although a few such as KICH and UCEC show the opposite, repressed pattern.

KICH, KIRC, and UCEC are the cancer types where ERVK9-11 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ERVK9-11 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	III,IV	−1.565	<.001	11	view →
KIRC	Female	All	+1.151	<.001	11	view →
UCEC	All	All	−0.485	<.001	8	view →
THCA	Male	All	−0.094	<.001	7	view →
KIRP	Female	II,III,IV	−0.902	<.001	6	view →
BRCA	All	III,IV	−0.289	<.001	6	view →
COAD	All	IV	−0.114	.021	3	view →
PRAD	All	All	−0.197	<.001	2	view →
LUAD	Female	II,III,IV	−0.181	<.001	2	view →
BLCA	Male	IV	−0.189	.015	1	view →
LUSC	All	All	+0.145	.015	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

ERVK9-11–KICH

Open the KICH breakdown →