ERVK3-1

Across TCGA patient cohorts, ERVK3-1 mutation is significantly associated with the RNA expression of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ERVK3-1-associated genes across cancer lineages are RBAK-RBAKDN, MIR8070, and MIR3193. Each is linked with ERVK3-1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ERVK3-1-to-partner and partner-to-ERVK3-1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RBAK-RBAKDN grouped by ERVK3-1-low versus ERVK3-1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ERVK3-1→partner) and Y-score (partner→ERVK3-1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RBAK-RBAKDN →	+0.139	+3.990	<.001	.002	3	1
UCEC	MIR8070 →	+0.762	+3.132	.001	.007	3	1
UCEC	MIR3193 →	+0.766	+3.253	<.001	.005	3	1
UCEC	MIR4298 →	+0.401	+4.206	<.001	.001	3	1
UCEC	EEF1E1-BLOC1S5 →	+0.051	+4.132	<.001	.009	3	1
UCEC	RNA5SP124 →	+0.520	+2.996	.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

RBAK-RBAKDN by ERVK3-1 expression — UCEC

Explore this box plot interactively →