ERVK3-1

Across TCGA pan-cancer cohorts, ERVK3-1 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated ERVK3-1 data layer compared with 5 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher ERVK3-1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ERVK3-1 expression acts as an unfavorable survival marker, although some lineages such as BLCA and BRCA show a favorable association.

KIRC, ACC, and LIHC are the cancer types where ERVK3-1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	II,III,IV	0.406	0.617	<.001	106	view →
ACC	OS	Median	All	0.453	0.771	<.001	99	view →
LIHC	OS	Tertile	All	0.651	0.854	<.001	79	view →
KICH	DFS	Median	III,IV	0.308	0.942	.001	74	view →
BLCA	DFS	Median	III,IV	0.393	0.223	.003	73	view →
BRCA	OS	Tertile	All	0.978	0.946	.001	61	view →
LGG	DFS	Median	All	0.623	0.853	<.001	52	view →
MESO	OS	Quartile	All	0.278	0.529	.001	34	view →
READ	OS	Median	II,III,IV	0.804	0.428	.008	29	view →
PRAD	DFS	Median	All	0.683	0.865	.006	26	view →
SKCM	DFS	Quartile	III,IV	0.337	0.759	<.001	23	view →
THYM	OS	Median	All	0.960	0.758	.006	17	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

ERVK3-1–KIRC (DFS)

Open the KIRC breakdown →