ERVK13-1

Across TCGA patient cohorts, ERVK13-1 mutation is significantly associated with the RNA expression of many other genes, with 2,990 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ERVK13-1-associated genes across cancer lineages are BTG3-AS1, CYTH4, and ESS2. Each is linked with ERVK13-1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ERVK13-1-to-partner and partner-to-ERVK13-1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BTG3-AS1 grouped by ERVK13-1-low versus ERVK13-1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ERVK13-1→partner) and Y-score (partner→ERVK13-1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	BTG3-AS1 →	+0.501	+3.353	<.001	.005	3	1
UCEC	CYTH4 →	+0.668	+2.332	.001	.003	3	1
UCEC	ESS2 →	+0.325	+3.459	.002	.005	3	1
UCEC	SRRD →	+0.534	+3.740	<.001	<.001	3	1
UCEC	TFIP11 →	+0.574	+3.042	.002	<.001	3	1
UCEC	TTC28 →	+0.816	+3.000	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,990 associations by consensus.

BTG3-AS1 by ERVK13-1 expression — UCEC

Explore this box plot interactively →