ERVK13-1

Across TCGA pan-cancer cohorts, ERVK13-1 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated ERVK13-1 data layer compared with 1 for mutation status.

The strongest signal is observed in uveal melanoma (UVM), where higher ERVK13-1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ERVK13-1 expression acts as an unfavorable survival marker, although some lineages such as UCS and BLCA show a favorable association.

UVM, UCS, and BLCA are the cancer types where ERVK13-1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Quartile	III,IV	0.188	0.832	<.001	44	view →
UCS	DFS	Median	IV	0.952	0.367	.001	42	view →
BLCA	OS	Quartile	II,III,IV	0.796	0.590	.001	40	view →
READ	OS	Quartile	All	0.946	0.283	.001	36	view →
KIRC	DFS	Quartile	All	0.457	0.706	.006	35	view →
LGG	DFS	Tertile	All	0.783	0.906	<.001	25	view →
BRCA	OS	Tertile	III,IV	0.949	0.833	.008	23	view →
PRAD	DFS	Median	All	0.847	0.923	.006	18	view →
OV	OS	Quartile	All	0.799	0.879	.008	18	view →
HNSC	DFS	Tertile	All	0.770	0.663	.008	15	view →
THYM	DFS	Median	III,IV	1.000	0.456	.006	13	view →
LUSC	DFS	Quartile	III,IV	0.299	0.951	.006	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

ERVK13-1–UVM (DFS)

Open the UVM breakdown →