ERVK13-1

Across TCGA patient cohorts, ERVK13-1 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ERVK13-1-associated genes across cancer lineages are EGFR_pY1173, MEK1, and N-Cadherin. Each is linked with ERVK13-1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ERVK13-1-to-partner and partner-to-ERVK13-1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1173 grouped by ERVK13-1-low versus ERVK13-1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ERVK13-1→partner) and Y-score (partner→ERVK13-1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1173 →	+0.084	+2.486	.029	.011	3	1
UCEC	MEK1 →	+0.361	+2.459	.041	.020	3	1
UCEC	N-Cadherin →	+0.303	+2.817	.003	.036	3	1
UCEC	p62 Lck ligand →	+0.366	+2.459	.020	.020	3	1
UCEC	PCNA →	+0.269	+3.584	.009	.002	3	1
UCEC	Annexin-1 →	+0.536	+2.459	.035	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

EGFR_pY1173 by ERVK13-1 expression — UCEC

Explore this box plot interactively →