ERVFRD-3

Across TCGA pan-cancer cohorts, ERVFRD-3 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated ERVFRD-3 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher ERVFRD-3 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated ERVFRD-3 expression acts as an unfavorable survival marker, although some lineages such as HNSC and READ show a favorable association.

HNSC, CESC, and READ are the cancer types where ERVFRD-3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.392	0.263	.001	126	view →
CESC	DFS	Median	II,III,IV	0.349	0.752	.004	64	view →
READ	OS	Median	All	0.852	0.317	<.001	63	view →
LUSC	OS	Median	III,IV	0.433	0.670	.004	44	view →
KIRP	DFS	Quartile	All	0.928	0.550	.006	41	view →
BRCA	OS	Tertile	III,IV	0.961	0.839	.001	29	view →
UCS	DFS	Median	IV	0.952	0.473	.018	24	view →
UVM	DFS	Median	III,IV	0.313	0.678	.002	14	view →
SKCM	OS	Tertile	III,IV	0.797	0.596	.009	13	view →
BLCA	DFS	Quartile	All	0.190	0.491	<.001	12	view →
DLBC	DFS	Median	All	0.575	0.880	.009	10	view →
ESCA	DFS	Tertile	II,III,IV	0.521	0.326	.018	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

ERVFRD-3–HNSC (DFS)

Open the HNSC breakdown →