ERVFRD-1

Across TCGA patient cohorts, ERVFRD-1 mutation is significantly associated with the RNA expression of many other genes, with 2,139 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ERVFRD-1-associated genes across cancer lineages are MRPS31P1, RNA5SP393, and RNU6-640P. Each is linked with ERVFRD-1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ERVFRD-1-to-partner and partner-to-ERVFRD-1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MRPS31P1 grouped by ERVFRD-1-low versus ERVFRD-1-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ERVFRD-1→partner) and Y-score (partner→ERVFRD-1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MRPS31P1 →	+0.384	+5.324	<.001	.003	3	1
SKCM	RNA5SP393 →	+0.574	+5.075	<.001	.001	3	1
SKCM	RNU6-640P →	+0.633	+4.352	<.001	.007	3	1
SKCM	OR13C3 →	+0.035	+5.080	<.001	.004	3	1
SKCM	RNU6-1127P →	+0.267	+4.867	<.001	.005	3	1
SKCM	ZNF705D →	+0.011	+5.469	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,139 associations by consensus.

MRPS31P1 by ERVFRD-1 expression — BRCA

Explore this box plot interactively →