ERVFRD-1

Across TCGA pan-cancer cohorts, ERVFRD-1 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated ERVFRD-1 data layer compared with 7 for mutation status.

The strongest signal is observed in uveal melanoma (UVM), where higher ERVFRD-1 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated ERVFRD-1 expression acts as an unfavorable survival marker, although some lineages such as UVM and HNSC show a favorable association.

UVM, HNSC, and KIRC are the cancer types where ERVFRD-1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	All	0.793	0.419	<.001	115	view →
HNSC	DFS	Quartile	III,IV	0.637	0.460	.004	90	view →
KIRC	OS	Median	All	0.720	0.534	<.001	57	view →
CESC	DFS	Median	II,III,IV	0.837	0.551	<.001	50	view →
SKCM	OS	Quartile	All	0.904	0.811	<.001	22	view →
LUAD	OS	Quartile	III,IV	0.641	0.145	.006	22	view →
LUSC	OS	Quartile	All	0.582	0.735	.007	18	view →
UCS	DFS	Median	IV	0.475	0.850	.023	18	view →
ESCA	OS	Median	III,IV	0.573	0.321	.009	16	view →
THYM	DFS	Quartile	All	0.948	0.503	.008	12	view →
MESO	DFS	Quartile	IV	0.609	0.273	.026	12	view →
THCA	DFS	Median	IV	0.959	0.550	.014	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

ERVFRD-1–UVM (DFS)

Open the UVM breakdown →