ERVFRD-1

Across TCGA patient cohorts, ERVFRD-1 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ERVFRD-1-associated genes across cancer lineages are eEF2, Lck, and Caspase-7-cleavedD198. Each is linked with ERVFRD-1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ERVFRD-1-to-partner and partner-to-ERVFRD-1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by ERVFRD-1-low versus ERVFRD-1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ERVFRD-1→partner) and Y-score (partner→ERVFRD-1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.282	+1.874	.032	.049	3	2
UCEC	Lck →	+0.166	+2.321	.024	.034	3	2
UCEC	Caspase-7-cleavedD198 →	+0.725	+2.604	<.001	.005	3	2
UCEC	Di-Ras3 →	-0.134	-1.502	.014	.030	3	2
UCEC	14-3-3_beta →	-0.086	-1.489	.020	.030	3	1
UCEC	ERK2 →	+0.162	+1.847	.022	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

eEF2 by ERVFRD-1 expression — UCEC

Explore this box plot interactively →