ERVFRD-1

Across TCGA cell cohorts, ERVFRD-1 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,209 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ERVFRD-1-associated GO terms across cancer lineages are Positive regulation of transcription of nucleolar large rRNA by RNA polymerase I, Mitochondrial tRNA wobble uridine modification, and RNA localization. Each is linked with ERVFRD-1 in more than 6 cancer types. Because this analysis shows association rather than direction, both ERVFRD-1-to-partner and partner-to-ERVFRD-1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of transcription of nucleolar large rRNA by RNA polymerase I grouped by ERVFRD-1-low versus ERVFRD-1-high in CNS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ERVFRD-1→partner) and Y-score (partner→ERVFRD-1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	Positive regulation of transcription of nucleolar large rRNA by RNA polymerase I →	+0.100	+0.040	.001	.002	3	6
CNS	Mitochondrial tRNA wobble uridine modification →	+0.078	+0.031	<.001	.004	3	5
BLOOD_Myeloma	RNA localization →	+0.046	+0.037	.003	.001	2	6
LARGE_INTESTINE	RNA export from nucleus →	+0.087	+0.062	<.001	<.001	1	7
UPPER_AERODIGESTIVE_TRACT	Negative regulation of T cell costimulation →	+0.100	+0.026	.001	<.001	3	5
LUNG_NSCLC_LUAD	Negative regulation of nucleobase-containing compound transport →	+0.096	+0.025	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,209 associations by consensus.

Positive regulation of transcription of nucleolar large rRNA by RNA polymerase I by ERVFRD-1 expression — CNS

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