ERVFRD-1

Across TCGA cell cohorts, ERVFRD-1 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. BONE shows the largest number of these associations.

The most reproducible ERVFRD-1-associated genes across cancer lineages are ADAM2, SPRR2G, and SMCP. Each is linked with ERVFRD-1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ERVFRD-1-to-partner and partner-to-ERVFRD-1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ADAM2 grouped by ERVFRD-1-low versus ERVFRD-1-high in BONE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ERVFRD-1→partner) and Y-score (partner→ERVFRD-1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	ADAM2 →	+0.049	+5.169	<.001	.004	3	1
BONE	SPRR2G →	+0.136	+5.169	<.001	.004	3	1
BONE	SMCP →	+0.046	+5.169	<.001	.004	3	1
BONE	OR5AR1 →	+0.043	+5.169	<.001	.004	3	1
BONE	OR5AP2 →	+0.036	+5.169	<.001	.004	3	1
BONE	OR5AN1 →	+0.026	+5.169	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

ADAM2 by ERVFRD-1 expression — BONE

Explore this box plot interactively →