ERVFRD-1

Across TCGA cell cohorts, ERVFRD-1 mutation is significantly associated with the mutation status of many other genes, with 786 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ERVFRD-1-associated genes across cancer lineages are DPYSL4, N4BP1, and ZNF544. Each is linked with ERVFRD-1 in more than 2 cancer types. Because this analysis shows association rather than direction, both ERVFRD-1-to-partner and partner-to-ERVFRD-1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DPYSL4 grouped by ERVFRD-1-low versus ERVFRD-1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ERVFRD-1→partner) and Y-score (partner→ERVFRD-1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	DPYSL4 →	+5.321	+5.894	.002	.002	1	3
BLOOD_Leukemia	N4BP1 →	+5.321	+5.894	.002	.002	1	3
BLOOD_Leukemia	ZNF544 →	+4.321	+5.285	.005	.005	1	3
BLOOD_Leukemia	AATF →	+4.736	+5.560	.003	.003	1	2
BONE	GCN1 →	+4.437	+5.000	.007	.007	1	2
LARGE_INTESTINE	ZNF850 →	+2.159	+3.807	.007	.007	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 786 associations by consensus.

DPYSL4 by ERVFRD-1 expression — BLOOD_Leukemia

Explore this box plot interactively →