Across TCGA patient cohorts, ERV3-1 mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ERV3-1-associated genes across cancer lineages are Bak, Caspase-7-cleavedD198, and EGFR_pY1068. Each is linked with ERV3-1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ERV3-1-to-partner and partner-to-ERV3-1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ERV3-1→partner) and Y-score (partner→ERV3-1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Bak →	+0.207	+1.700	.031	.042	3	2
UCEC	Caspase-7-cleavedD198 →	+0.521	+2.135	.022	.010	3	2
UCEC	EGFR_pY1068 →	-0.266	-1.678	.005	.023	3	1
UCEC	A-Raf_pS299 →	-0.162	-2.115	<.001	.017	3	1
UCEC	ERK2 →	+0.202	+1.678	.006	.023	3	1
UCEC	Gab2 →	+0.463	+2.807	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

Exploration

ERV3-1 survival (RNA) · tumor vs normal (RNA) · all ERV3-1 data types