ERO1A

mutation — cross-omics
Cross-omicsMUTATION → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, ERO1A mutation is significantly associated with the RNA expression of many other genes, with 4,310 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ERO1A-associated genes across cancer lineages are MED28P4, SNORD116-15, and RNA5SP146. Each is linked with ERO1A in more than 1 cancer types. Because this analysis shows association rather than direction, both ERO1A-to-partner and partner-to-ERO1A results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ERO1A→partner) and Y-score (partner→ERO1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
COADMED28P4 →+0.279+5.037<.001.00232
SKCMSNORD116-15 →+0.922+3.952<.001.00732
SKCMRNA5SP146 →+0.195+4.282.002.00932
UCECRNU6-379P →+0.364+1.694<.001.00532
UCECRNU6-961P →+0.117+4.060<.001<.00132
UCECRN7SKP214 →+0.226+1.794<.001.00132
Each partner links to its Q-omics profile. Showing the 6 strongest of 4,310 associations by consensus.

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