ERN2

Across TCGA cell cohorts, ERN2 mutation is significantly associated with the RNA expression of many other genes, with 38 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ERN2-associated genes across cancer lineages are OR10Z1, OR9I1, and OR2AK2. Each is linked with ERN2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ERN2-to-partner and partner-to-ERN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10Z1 grouped by ERN2-low versus ERN2-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ERN2→partner) and Y-score (partner→ERN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	OR10Z1 →	+0.011	+3.662	<.001	.001	3	1
LUNG_SCLC	OR9I1 →	+0.017	+4.643	<.001	.004	3	1
LUNG_SCLC	OR2AK2 →	+0.090	+4.269	.007	.005	3	1
LUNG_SCLC	PRR20B →	+0.022	+4.269	.001	.005	3	1
LUNG_SCLC	PRR20A →	+0.022	+4.269	.001	.005	3	1
LUNG_SCLC	PRR20D →	+0.022	+4.269	.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

OR10Z1 by ERN2 expression — STOMACH

Explore this box plot interactively →