ERMN

Across TCGA patient cohorts, ERMN mutation is significantly associated with the RNA expression of many other genes, with 2,668 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ERMN-associated genes across cancer lineages are MIR4765, MIR6803, and RNU6-342P. Each is linked with ERMN in more than 1 cancer types. Because this analysis shows association rather than direction, both ERMN-to-partner and partner-to-ERMN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4765 grouped by ERMN-low versus ERMN-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ERMN→partner) and Y-score (partner→ERMN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MIR4765 →	+0.280	+4.197	.004	.009	3	2
UCEC	MIR6803 →	+0.097	+3.777	<.001	.007	3	2
HNSC	RNU6-342P →	+0.646	+5.241	<.001	.007	3	2
HNSC	TXNL4AP1 →	+0.118	+5.069	<.001	.008	3	2
UCEC	EI24 →	+0.435	+2.584	.001	<.001	3	2
UCEC	ATP5MC3 →	+0.384	+1.928	.008	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,668 associations by consensus.

MIR4765 by ERMN expression — LUAD

Explore this box plot interactively →