ERMN

Across TCGA pan-cancer cohorts, ERMN RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of ERMN’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where ERMN RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ERMN is over-expressed in tumor, although a few such as LUSC and LIHC show the opposite, repressed pattern.

KIRC, UCEC, and BRCA are the cancer types where ERMN tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ERMN RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	II,III,IV	+0.145	<.001	7	view →
UCEC	All	III,IV	+2.303	<.001	6	view →
BRCA	All	III,IV	+0.990	<.001	6	view →
STAD	Male	All	+0.309	<.001	4	view →
COAD	Male	All	+0.303	.014	4	view →
BLCA	Male	All	+0.279	.018	4	view →
LUSC	Male	III,IV	−0.545	.040	1	view →
CHOL	All	All	+0.292	.038	1	view →
KICH	All	All	+0.148	.035	1	view →
KIRP	Male	All	+0.146	.028	1	view →
LIHC	Male	All	−0.072	.034	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

ERMN–KIRC

Open the KIRC breakdown →