ERMARD

Across TCGA patient cohorts, ERMARD mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ERMARD-associated genes across cancer lineages are eIF4E, Caspase-7-cleavedD198, and ASNS. Each is linked with ERMARD in more than 3 cancer types. Because this analysis shows association rather than direction, both ERMARD-to-partner and partner-to-ERMARD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by ERMARD-low versus ERMARD-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ERMARD→partner) and Y-score (partner→ERMARD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.190	+1.925	.012	.005	2	4
UCEC	Caspase-7-cleavedD198 →	+0.592	+1.604	.005	.041	3	2
COAD	ASNS →	+0.699	+3.008	<.001	.019	3	1
COAD	Cyclin-D1 →	+0.162	+3.008	.016	.019	3	1
SKCM	Rictor →	-0.452	-3.000	.014	.036	3	1
SKCM	CDK1 →	+0.245	+3.000	.013	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

eIF4E by ERMARD expression — UCEC

Explore this box plot interactively →