ERMARD

Across TCGA pan-cancer cohorts, ERMARD RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of ERMARD’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where ERMARD RNA is repressed in tumor relative to normal tissue. In most cancer types ERMARD is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KICH, COAD, and THCA are the cancer types where ERMARD tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ERMARD RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	II,III,IV	−1.520	<.001	11	view →
COAD	All	IV	+0.767	<.001	10	view →
THCA	All	All	−0.266	<.001	8	view →
LIHC	All	All	+0.320	<.001	7	view →
LUAD	Female	II,III,IV	−0.323	.009	5	view →
STAD	All	All	+0.648	<.001	4	view →
KIRP	All	All	−0.422	.008	4	view →
HNSC	All	III,IV	+0.323	.007	4	view →
UCEC	All	All	−0.314	.035	4	view →
CHOL	All	II,III,IV	+1.264	.023	3	view →
KIRC	All	All	+0.214	.001	3	view →
BLCA	All	III,IV	+0.373	.005	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

ERMARD–KICH

Open the KICH breakdown →