Across TCGA patient cohorts, ERICH4 mutation is significantly associated with the RNA expression of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ERICH4-associated genes across cancer lineages are IGHV3OR16-6, IGKV2OR2-7D, and IGHV3OR16-8. Each is linked with ERICH4 in more than 1 cancer types. Because this analysis shows association rather than direction, both ERICH4-to-partner and partner-to-ERICH4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ERICH4→partner) and Y-score (partner→ERICH4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IGHV3OR16-6 →	+0.809	+2.982	<.001	.006	3	1
UCEC	IGKV2OR2-7D →	+0.287	+4.034	<.001	.001	3	1
UCEC	IGHV3OR16-8 →	+1.321	+3.535	<.001	.007	3	1
UCEC	BNIP3P4 →	+0.092	+3.747	<.001	.003	3	1
UCEC	LINC02104 →	+0.359	+3.468	<.001	.006	3	1
UCEC	IGKV1OR2-6 →	+1.755	+3.511	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

Exploration

ERICH4 survival (RNA) · tumor vs normal (RNA) · all ERICH4 data types