ERICD

Across TCGA pan-cancer cohorts, ERICD RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of ERICD’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where ERICD RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ERICD is over-expressed in tumor, although a few such as UCEC and KICH show the opposite, repressed pattern.

KIRP, COAD, and HNSC are the cancer types where ERICD tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ERICD RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	All	III,IV	+0.989	<.001	11	view →
COAD	Female	All	+0.509	<.001	11	view →
HNSC	Male	III,IV	+0.486	<.001	11	view →
THCA	Male	II,III,IV	+0.562	<.001	8	view →
LIHC	Female	All	+0.447	<.001	8	view →
STAD	All	II,III,IV	+0.385	.001	6	view →
LUAD	All	II,III,IV	+0.341	.005	4	view →
CHOL	All	All	+1.116	<.001	3	view →
UCEC	All	All	−0.379	.029	2	view →
KICH	All	All	−0.375	.017	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

ERICD–KIRP

Open the KIRP breakdown →