ERI3

Across TCGA patient cohorts, ERI3 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ERI3-associated genes across cancer lineages are Caspase-7-cleavedD198, MEK1, and p27_pT157. Each is linked with ERI3 in more than 1 cancer types. Because this analysis shows association rather than direction, both ERI3-to-partner and partner-to-ERI3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by ERI3-low versus ERI3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ERI3→partner) and Y-score (partner→ERI3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.998	+3.189	<.001	.010	3	2
UCEC	MEK1 →	+0.418	+3.169	.022	.019	3	1
UCEC	p27_pT157 →	-0.064	-2.321	.028	.035	2	1
UCEC	P-Cadherin →	-0.176	-2.308	.015	.036	2	1
UCEC	c-Jun_pS73 →	-0.186	-3.459	.020	.005	2	1
UCEC	c-Kit →	-0.276	-3.459	.018	.005	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

Caspase-7-cleavedD198 by ERI3 expression — UCEC

Explore this box plot interactively →