ERI3-IT1

Across TCGA pan-cancer cohorts, ERI3-IT1 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of ERI3-IT1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where ERI3-IT1 RNA is repressed in tumor relative to normal tissue. In most cancer types ERI3-IT1 is over-expressed in tumor, although a few such as THCA and UCEC show the opposite, repressed pattern.

THCA, CHOL, and LIHC are the cancer types where ERI3-IT1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ERI3-IT1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	All	−0.222	<.001	5	view →
CHOL	All	II,III,IV	+0.660	<.001	4	view →
LIHC	All	All	+0.044	.011	3	view →
UCEC	All	IV	+0.765	.025	2	view →
UCEC	All	All	−0.231	.006	2	view →
COAD	All	II,III,IV	−0.163	.020	2	view →
KIRC	All	All	+0.114	.004	2	view →
HNSC	All	II,III,IV	+0.064	.020	2	view →
KICH	All	II,III,IV	+0.088	.043	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 8 lineages.

ERI3-IT1–THCA

Open the THCA breakdown →