Across TCGA pan-cancer cohorts, ERHP2 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of ERHP2’s most consistent transcriptional readouts.
The strongest signal is observed in thyroid carcinoma (THCA), where ERHP2 RNA is repressed in tumor relative to normal tissue. In most cancer types ERHP2 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.
THCA and LIHC are the cancer types where ERHP2 tumor–normal differential expression is most reproducible.