ERG

Across TCGA pan-cancer cohorts, ERG Mutation is linked to patient survival in 9 of 34 cancer types, making it a survival-associated ERG data layer compared with 21 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in lymphoid neoplasm diffuse large b-cell lymphoma (DLBC), where higher ERG Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated ERG expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.

DLBC, CESC, and LGG are the cancer types where ERG Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
DLBC	OS	Median	II,III,IV	0.172	0.949	<.001	30	view →
CESC	DFS	Median	III,IV	0.240	0.726	.015	6	view →
LGG	OS	Median	All	0.461	0.812	.009	6	view →
ACC	OS	Median	All	0.118	0.624	.038	6	view →
BLCA	OS	Median	All	0.188	0.687	.020	6	view →
UCEC	DFS	Median	All	0.941	0.623	.020	6	view →
SKCM	OS	Median	II,III,IV	0.893	0.722	.039	5	view →
SARC	OS	Median	All	0.239	0.826	.002	3	view →
STAD	DFS	Median	II,III,IV	0.210	0.689	.014	3	view →

Pink = unfavorable, green = favorable. Showing the 9 strongest of 9 lineages.

ERG–DLBC (OS)

Open the DLBC breakdown →