ERG

Across TCGA pan-cancer cohorts, ERG RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of ERG’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where ERG RNA is repressed in tumor relative to normal tissue. In most cancer types ERG is over-expressed in tumor, although a few such as LUAD and KICH show the opposite, repressed pattern.

LUAD, KICH, and HNSC are the cancer types where ERG tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ERG RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	III,IV	−2.206	<.001	11	view →
KICH	Female	All	−1.782	<.001	11	view →
HNSC	Female	IV	+1.521	<.001	10	view →
LUSC	Female	II,III,IV	−2.507	<.001	9	view →
KIRP	Male	All	−1.902	<.001	9	view →
THCA	All	All	−0.405	<.001	9	view →
BLCA	Male	All	−1.038	.003	7	view →
UCEC	All	All	−1.677	<.001	6	view →
BRCA	All	II,III,IV	−1.376	<.001	6	view →
KIRC	All	All	+0.557	<.001	5	view →
PRAD	All	All	+1.985	<.001	2	view →
PAAD	All	All	−1.135	.036	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

ERG–LUAD

Open the LUAD breakdown →