ERG

Across TCGA pan-cancer cohorts, ERG mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated ERG data layer compared with 21 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher ERG mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated ERG expression acts as an unfavorable survival marker, although some lineages such as CCRCC and HNSC show a favorable association.

LUAD, CCRCC, and PDAC are the cancer types where ERG mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Quartile	II,III,IV	0.639	1.000	.001	27	view →
CCRCC	DFS	Tertile	III,IV	1.000	0.735	.008	24	view →
PDAC	OS	Quartile	All	0.235	0.742	.012	12	view →
HNSC	OS	Quartile	III,IV	0.945	0.729	.042	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

ERG–LUAD (DFS)

Open the LUAD breakdown →