ERG

Across TCGA patient cohorts, ERG protein abundance is significantly associated with the RNA expression of many other genes, with 14,846 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible ERG-associated genes across cancer lineages are MYCT1, RAMP2, and LYVE1. Each is linked with ERG in more than 6 cancer types. Because this analysis shows association rather than direction, both ERG-to-partner and partner-to-ERG results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ERG versus MYCT1 in CCRCC, with a Pearson correlation of 0.81.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ERG→partner) and Y-score (partner→ERG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	MYCT1 →	+1.386	+0.585	<.001	<.001	3	7
CCRCC	RAMP2 →	+1.318	+0.591	<.001	<.001	3	6
PDAC	LYVE1 →	+1.303	+0.511	<.001	.001	3	6
CCRCC	DIPK2B →	+1.354	+0.587	<.001	<.001	3	6
CCRCC	ROBO4 →	+1.131	+0.576	<.001	<.001	3	6
CCRCC	BCL6B →	+1.305	+0.572	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,846 associations by consensus.

ERG vs MYCT1 — CCRCC

Explore this scatter interactively →