ERG

Across TCGA patient cohorts, ERG mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ERG-associated genes across cancer lineages are ER-alpha, C-Raf_pS338, and A-Raf_pS299. Each is linked with ERG in more than 1 cancer types. Because this analysis shows association rather than direction, both ERG-to-partner and partner-to-ERG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ER-alpha grouped by ERG-low versus ERG-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ERG→partner) and Y-score (partner→ERG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	ER-alpha →	-0.169	-2.222	.031	.010	3	2
SKCM	C-Raf_pS338 →	-0.115	-2.222	.030	.010	3	2
UCEC	A-Raf_pS299 →	-0.127	-2.247	.001	.001	3	2
UCEC	mTOR_pS2448 →	-0.132	-1.664	.007	.019	3	2
UCEC	Notch1 →	+0.170	+1.652	<.001	.006	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.307	-1.678	.038	.021	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

ER-alpha by ERG expression — SKCM

Explore this box plot interactively →