ERG

Across TCGA cell cohorts, ERG RNA expression is significantly associated with the go_rna of many other GO terms, with 1,958 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ERG-associated GO terms across cancer lineages are Mitochondrial respirasome assembly, GDF15-GFRAL signaling pathway, and Regulation of kidney size. Each is linked with ERG in more than 3 cancer types. Because this analysis shows association rather than direction, both ERG-to-partner and partner-to-ERG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Mitochondrial respirasome assembly grouped by ERG-low versus ERG-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ERG→partner) and Y-score (partner→ERG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Mitochondrial respirasome assembly →	+0.101	+1.158	.001	.006	3	4
BLOOD_Leukemia	GDF15-GFRAL signaling pathway →	-0.746	-2.868	<.001	<.001	3	4
LUNG_SCLC	Regulation of kidney size →	-0.839	-1.035	.001	.002	3	4
BLOOD_Leukemia	Positive regulation of protein import into nucleus →	+0.029	+1.722	.008	<.001	3	4
BLOOD_Leukemia	mRNA transport →	+0.046	+1.709	.004	.005	3	4
BLOOD_Leukemia	Microtubule nucleation →	+0.060	+1.698	.002	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,958 associations by consensus.

Mitochondrial respirasome assembly by ERG expression — SOFT_TISSUE

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