ERG

Across TCGA cell cohorts, ERG mutation is significantly associated with the RNA expression of many other genes, with 25 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ERG-associated genes across cancer lineages are PABPC1L2B, UCP1, and S100G. Each is linked with ERG in more than 1 cancer types. Because this analysis shows association rather than direction, both ERG-to-partner and partner-to-ERG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PABPC1L2B grouped by ERG-low versus ERG-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ERG→partner) and Y-score (partner→ERG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	PABPC1L2B →	+0.099	+4.736	.009	.009	3	1
LARGE_INTESTINE	UCP1 →	+0.224	+2.923	<.001	.004	3	1
LARGE_INTESTINE	S100G →	+1.020	+2.688	<.001	.008	3	1
LARGE_INTESTINE	PYGO1 →	+1.287	+3.439	<.001	.003	3	1
LARGE_INTESTINE	KCND3 →	+0.307	+3.548	.004	.004	3	1
LARGE_INTESTINE	OLIG1 →	+0.127	+3.938	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

PABPC1L2B by ERG expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →