ERFE

Across TCGA patient cohorts, ERFE mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ERFE-associated genes across cancer lineages are 14-3-3_beta, eIF4E, and FOXO3a. Each is linked with ERFE in more than 1 cancer types. Because this analysis shows association rather than direction, both ERFE-to-partner and partner-to-ERFE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by ERFE-low versus ERFE-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ERFE→partner) and Y-score (partner→ERFE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.122	-2.973	.015	.035	3	1
UCEC	eIF4E →	+0.235	+2.321	.026	.035	3	1
UCEC	FOXO3a →	-0.120	-3.292	.018	.010	3	1
UCEC	JNK_pT183_Y185 →	-0.230	-3.446	.006	.005	3	1
UCEC	JNK2 →	+0.275	+3.009	.005	.019	3	1
UCEC	Ku80 →	+0.355	+3.013	.002	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

14-3-3_beta by ERFE expression — UCEC

Explore this box plot interactively →