ERF

Across TCGA patient cohorts, ERF mutation is significantly associated with the RNA expression of many other genes, with 1,858 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ERF-associated genes across cancer lineages are VN1R25P, RN7SL354P, and TUBGCP5. Each is linked with ERF in more than 2 cancer types. Because this analysis shows association rather than direction, both ERF-to-partner and partner-to-ERF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VN1R25P grouped by ERF-low versus ERF-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ERF→partner) and Y-score (partner→ERF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	VN1R25P →	+0.051	+5.837	<.001	.001	3	3
UCEC	RN7SL354P →	+0.151	+1.843	.008	.004	3	3
UCEC	TUBGCP5 →	+0.538	+3.354	<.001	<.001	3	2
UCEC	SENP3-EIF4A1 →	+0.095	+3.174	.004	<.001	3	2
UCEC	COX15 →	+0.460	+3.008	<.001	<.001	3	2
UCEC	DGKE →	+0.653	+3.970	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,858 associations by consensus.

VN1R25P by ERF expression — CESC

Explore this box plot interactively →