EREG

Across TCGA patient cohorts, EREG mutation is significantly associated with the RNA expression of many other genes, with 1,426 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EREG-associated genes across cancer lineages are BAG3, SAA4, and INTS4. Each is linked with EREG in more than 1 cancer types. Because this analysis shows association rather than direction, both EREG-to-partner and partner-to-EREG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BAG3 grouped by EREG-low versus EREG-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EREG→partner) and Y-score (partner→EREG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	BAG3 →	+0.663	+3.000	.001	.001	3	2
UCEC	SAA4 →	-0.762	-3.000	.005	.001	3	1
UCEC	INTS4 →	+0.335	+3.831	.008	<.001	3	1
UCEC	CPSF7 →	+0.445	+2.617	.001	.005	3	1
UCEC	SOGA1 →	+0.572	+2.343	.003	.003	3	1
UCEC	MTMR12 →	+0.577	+3.330	.004	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,426 associations by consensus.

BAG3 by EREG expression — UCEC

Explore this box plot interactively →