EREG

Across TCGA pan-cancer cohorts, EREG RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated EREG data layer compared with 3 for mutation status.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher EREG RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated EREG expression acts as an unfavorable survival marker, although some lineages such as COAD and READ show a favorable association.

KIRC, UVM, and CESC are the cancer types where EREG RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.559	0.687	<.001	158	view →
UVM	OS	Tertile	II,III,IV	0.478	0.794	<.001	129	view →
CESC	OS	Median	All	0.699	0.886	<.001	110	view →
ACC	DFS	Median	All	0.210	0.615	<.001	103	view →
PAAD	DFS	Tertile	All	0.225	0.529	<.001	63	view →
LUSC	OS	Median	All	0.720	0.826	<.001	48	view →
LUAD	DFS	Median	All	0.744	0.835	.001	33	view →
COAD	OS	Quartile	All	0.938	0.799	.001	32	view →
READ	DFS	Median	II,III,IV	0.678	0.360	.001	32	view →
SCLC	DFS	Tertile	All	0.616	0.323	.001	29	view →
STAD	DFS	Quartile	IV	0.199	0.621	.024	22	view →
BLCA	OS	Tertile	All	0.665	0.789	.011	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

EREG–KIRC (DFS)

Open the KIRC breakdown →