EREG

Across TCGA patient cohorts, EREG mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EREG-associated genes across cancer lineages are Annexin-1, Bak, and JNK_pT183_Y185. Each is linked with EREG in more than 1 cancer types. Because this analysis shows association rather than direction, both EREG-to-partner and partner-to-EREG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Annexin-1 grouped by EREG-low versus EREG-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EREG→partner) and Y-score (partner→EREG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Annexin-1 →	+0.620	+2.827	.011	.035	3	2
UCEC	Bak →	+0.324	+3.700	.005	.001	3	2
UCEC	JNK_pT183_Y185 →	-0.200	-3.169	.010	.019	3	1
UCEC	p62 Lck ligand →	+0.434	+2.331	.004	.019	3	1
UCEC	PRAS40_pT246 →	+0.181	+1.887	.023	.031	3	1
UCEC	S6_pS240_S244 →	+0.405	+3.000	.032	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

Annexin-1 by EREG expression — UCEC

Explore this box plot interactively →