EREG

Across TCGA cell cohorts, EREG RNA expression is significantly associated with the go_rna of many other GO terms, with 2,775 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible EREG-associated GO terms across cancer lineages are Ovarian cumulus expansion, Luteinizing hormone signaling pathway, and ERBB4-ERBB4 signaling pathway. Each is linked with EREG in more than 14 cancer types. Because this analysis shows association rather than direction, both EREG-to-partner and partner-to-EREG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ovarian cumulus expansion grouped by EREG-low versus EREG-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (EREG→partner) and Y-score (partner→EREG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Ovarian cumulus expansion →	+1.939	+3.897	<.001	<.001	3	15
LUNG_NSCLC_LUAD	Luteinizing hormone signaling pathway →	+2.066	+4.354	<.001	<.001	3	15
LIVER	ERBB4-ERBB4 signaling pathway →	+1.196	+3.733	.004	.001	3	13
LUNG_NSCLC_LUAD	Antral ovarian follicle growth →	+1.580	+3.745	<.001	<.001	3	11
LUNG_NSCLC_LUAD	Fused antrum stage →	+1.580	+3.745	<.001	<.001	3	11
LARGE_INTESTINE	Cellular response to external stimulus →	+0.089	+2.815	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,775 associations by consensus.

Ovarian cumulus expansion by EREG expression — LIVER

Explore this box plot interactively →