ERCC8

Across TCGA patient cohorts, ERCC8 RNA expression is significantly associated with the RNA expression of many other genes, with 20,346 significant associations in total. ACC shows the largest number of these associations.

The most reproducible ERCC8-associated genes across cancer lineages are ADNP2, MRPS27, and MSH3. Each is linked with ERCC8 in more than 33 cancer types. Because this analysis shows association rather than direction, both ERCC8-to-partner and partner-to-ERCC8 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ERCC8 versus ADNP2 in DLBC, with a Pearson correlation of 0.61.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ERCC8→partner) and Y-score (partner→ERCC8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
DLBC	ADNP2 →	+1.445	+0.754	<.001	<.001	3	34
KICH	MRPS27 →	+0.984	+0.860	<.001	<.001	3	34
UVM	MSH3 →	+1.641	+0.946	<.001	<.001	3	34
UVM	TRIM23 →	+1.431	+0.968	<.001	<.001	3	34
UVM	TRAPPC13 →	+1.684	+0.986	<.001	<.001	3	34
UVM	PANK3 →	+1.529	+0.984	<.001	<.001	3	34

Each partner links to its Q-omics profile. Showing the 6 strongest of 20,346 associations by consensus.

ERCC8 vs ADNP2 — DLBC

Explore this scatter interactively →