ERCC6L2

Across TCGA cell cohorts, ERCC6L2 mutation is significantly associated with the RNA expression of many other genes, with 626 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ERCC6L2-associated genes across cancer lineages are GNAT3, SPRR5, and SLC13A2. Each is linked with ERCC6L2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ERCC6L2-to-partner and partner-to-ERCC6L2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GNAT3 grouped by ERCC6L2-low versus ERCC6L2-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ERCC6L2→partner) and Y-score (partner→ERCC6L2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	GNAT3 →	+0.030	+4.807	<.001	.006	3	1
BLOOD_Myeloma	SPRR5 →	+0.320	+4.807	<.001	.006	3	1
BLOOD_Myeloma	SLC13A2 →	+0.013	+4.807	<.001	.006	3	1
CNS	PRAMEF6 →	+0.131	+5.754	<.001	.002	3	1
OVARY	GHRH →	+0.296	+5.196	<.001	.005	3	1
OVARY	MS4A10 →	+0.013	+5.196	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 626 associations by consensus.

GNAT3 by ERCC6L2 expression — BLOOD_Myeloma

Explore this box plot interactively →