Across TCGA cell cohorts, ERCC6 mutation is significantly associated with the RNA expression of many other genes, with 797 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ERCC6-associated genes across cancer lineages are CLPSL1, OR6B2, and FAM160A1. Each is linked with ERCC6 in more than 1 cancer types. Because this analysis shows association rather than direction, both ERCC6-to-partner and partner-to-ERCC6 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ERCC6→partner) and Y-score (partner→ERCC6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	CLPSL1 →	+0.350	+3.766	<.001	.004	3	2
BREAST	OR6B2 →	+0.031	+3.584	.006	.004	3	2
LARGE_INTESTINE	FAM160A1 →	+0.786	+2.628	.001	.002	3	2
LARGE_INTESTINE	ACER1 →	+0.070	+2.453	<.001	<.001	3	2
LUNG_NSCLC_LUSC	TEX28 →	+0.183	+4.643	<.001	.008	3	1
KIDNEY	KCNA1 →	+0.006	+5.000	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 797 associations by consensus.

Exploration

ERCC6 survival (RNA) · tumor vs normal (RNA) · all ERCC6 data types