ERCC5

Across TCGA cell cohorts, ERCC5 mutation is significantly associated with the RNA expression of many other genes, with 28 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ERCC5-associated genes across cancer lineages are OCSTAMP, OR5B12, and P2RY13. Each is linked with ERCC5 in more than 1 cancer types. Because this analysis shows association rather than direction, both ERCC5-to-partner and partner-to-ERCC5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OCSTAMP grouped by ERCC5-low versus ERCC5-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ERCC5→partner) and Y-score (partner→ERCC5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	OCSTAMP →	+0.008	+3.449	.001	.004	3	1
CNS	OR5B12 →	+0.011	+4.459	.001	<.001	3	1
CNS	P2RY13 →	+0.017	+3.321	<.001	.006	3	1
CNS	PRAMEF20 →	+0.215	+3.459	.003	.006	3	1
CNS	CFAP97D2 →	+0.037	+3.730	<.001	.002	3	1
LARGE_INTESTINE	C2orf42 →	+0.775	+3.215	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

OCSTAMP by ERCC5 expression — CNS

Explore this box plot interactively →