ERCC3

Across TCGA patient cohorts, ERCC3 mutation is significantly associated with the RNA expression of many other genes, with 4,717 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ERCC3-associated genes across cancer lineages are GSKIP, PSMA4, and P4HB. Each is linked with ERCC3 in more than 3 cancer types. Because this analysis shows association rather than direction, both ERCC3-to-partner and partner-to-ERCC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GSKIP grouped by ERCC3-low versus ERCC3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ERCC3→partner) and Y-score (partner→ERCC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GSKIP →	+0.461	+1.807	<.001	<.001	3	4
UCEC	PSMA4 →	+0.379	+2.082	.001	<.001	3	4
COAD	P4HB →	+0.495	+3.362	.005	.005	3	3
COAD	MMP12 →	+1.521	+3.335	.006	.005	3	3
LUAD	SNRPGP7 →	+0.515	+5.888	<.001	.002	3	3
UCEC	OIP5 →	+0.914	+2.343	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,717 associations by consensus.

GSKIP by ERCC3 expression — UCEC

Explore this box plot interactively →