ERCC2

Across TCGA patient cohorts, ERCC2 protein abundance is significantly associated with the RNA expression of many other genes, with 13,964 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible ERCC2-associated genes across cancer lineages are KIF18A, TOP2A, and KIF11. Each is linked with ERCC2 in more than 6 cancer types. Because this analysis shows association rather than direction, both ERCC2-to-partner and partner-to-ERCC2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ERCC2 versus KIF18A in HNSC, with a Pearson correlation of 0.48.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ERCC2→partner) and Y-score (partner→ERCC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	KIF18A →	+0.920	+0.156	<.001	<.001	3	7
LUAD	TOP2A →	+1.018	+0.146	<.001	<.001	3	7
HNSC	KIF11 →	+0.782	+0.183	<.001	<.001	3	7
GBM	MELK →	+0.985	+0.242	<.001	<.001	3	7
BRCA	TPX2 →	+1.027	+0.210	<.001	.001	3	6
GBM	GINS1 →	+0.831	+0.248	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,964 associations by consensus.

ERCC2 vs KIF18A — HNSC

Explore this scatter interactively →